A hybrid constructive algorithm incorporating teaching-learning based optimization for neural network training

In neural networks, simultaneous determination of the optimum structure and weights is a challenge. This paper proposes a combination of teaching-learning based optimization (TLBO) algorithm and a constructive algorithm (CA) to cope with the challenge. In literature, TLBO is used to choose proper weights, while CA is adopted to construct different structures in order to select the proper one. In this study, the basic TLBO algorithm along with an improved version of this algorithm for network weights selection are utilized. Meanwhile, as a constructive algorithm, a novel modification to multiple operations, using statistical tests (MOST), is applied and tested to choose the proper structure. The proposed combinatorial algorithms are applied to ten classification problems and two-time-series prediction problems, as the benchmark. The results are evaluated based on training and testing error, network complexity and mean-square error. The experimental results illustrate that the proposed hybrid method of the modified MOST constructive algorithm and the improved TLBO (MCO-ITLBO) algorithm outperform the others; moreover, they have been proven by Wilcoxon statistical tests as well. The proposed method demonstrates less average error with less complexity in the network structure

24-Epibrassinolide enhanced the quality parameters and phytochemical contents of table grape

Enhancing the nutritional quality of fruits using safe and environmental friendly methods has become of the most important targets in modern fruit production systems. Brassinosteroids, a new group of phytohormones with positive roles on human health, have been shown to modulate a wide range of plant activities and enhance fruit quality in some crops. This study was conducted to examine the effect of 24-Epibrassinolide (EBL), a synthetic brassinosteroid, on quality attributes and some active bio-compounds of “Thompson seedless” table grapes. Grape vines and bunches were sprayed with EBL (at 0, 3 and/or 6 µmol L-1) at three different stages (4 weeks after fool bloom, veraison stage and 1 day before harvest). As a novel finding in seedless grapes, exogenous EBL substantially enhanced soluble solids content, total organic acids, antioxidants, phenolics and ascorbic acid levels in treated berries. Also the activity of catalase and polyphenol oxidase enzymes was increased. There was no significant difference between the two brassinosteroid levels in most cases. EBL showed a good potential for enhancing table grape phytonutrients, nutritional quality and phytochemical contents and is introduced as a safe compound to be used in table grape production programs.

Effects of salicylic acid application on two almond cultivars under salinity stress

The effects of salinity stress on the physiological processes and biochemical compounds of plants were reported. Salicylic acid (SA), as one of the main phytohormones, is a signal molecule that alleviates the negative influences of salinity. This study was conducted to investigate the protective role of SA in improving the salinity tolerance of two almond cultivars. Two almond cultivars (\u27Tuono\u27 and \u27Sahand\u27) grafted on the GN (Garnem) rootstock were exposed to different levels of salinity stress (0, 2, 6 and 8 dS·m-1) and treated with SA (0, 1 and 2 mM). The results showed that salinity stress significantly reduced the plant height, Fv/Fm, protein and total phenolic content (TPC), whereas Na and Cl content in roots, proline content and antioxidant enzymes activities, including superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), guaiacol peroxidase (POD) and glutathione peroxidase (GPX), significantly increased in response to salinity stress. Rootstock and scion diameter, and also leaves number of selected shoots significantly increased at 2 and 6 dS·m-1 of salinity, and then significantly decreased at 8 dS·m-1 of salinity. Furthermore, it was found SA treatment significantly alleviated the negative effects of salinity by enhancing morphological characteristics, Fv/Fm, accumulation of Na and Cl in roots, proline content, protein and TPC and also by enhancing the SOD, CAT, APX, POD and GPX activities. Taken together, the results showed that \u27Sahand\u27 cultivar treated with SA had a better response to salinity stress compared with \u27Tuono\u27 cultivar. Therefore, the use of \u27Sahand\u27 cultivar and application of SA could be recommended as a practical tool under salinity conditions

The reliability and validity of the persian version of sinonasal outcome test 22 (Snot22) questionnaires

Background: The quality of life (QOL) is an important indicator for disease-severity classification and outcome measurement in obtaining treatment sinonasal diseases. The sinonasal outcome test 22 (SNOT 22) questionnaire has been introduced as the best specific sinonasal instrument for QOL measurement. Objectives: To prepare a valid and reliable Persian language version of SNOT 22 questionnaire. Patients and Methods: After forward and backward translation of the original version of SNOT 22 questionnaire from English to Persian, a group of patients with nasal septal deviation who need septal surgery and another group of healthy volunteers answered the Persian version of the questionnaire. The responsiveness rate, validity (Pearson correlations and differential validity) and reliability (internal consistency and test-retest reliability) of the 22 items of the questionnaire was calculated. P value < 0.05 was considered significant. Results: Thirty adults with nasal septal deviation need surgical correction and 30 healthy volunteers were included (mean age 30.4 ± 7.1 vs. 33 ± 6.7, P value = 0.148). The questionnaire was introduced to subjects two times with a two-week-period gap. Total responsiveness rate for 22 items was more than 97%. The total Cronbach's Alfa coefficient was 0.898 (ranging 0.890-0.903). The Pearson correlations were 0.85 and 0.96 for patients and healthy volunteers, respectively. The mean total score were 25.6 ± 13.3 (range 6-52) and 7.6 ± 9.1 (range 0-45) in patients and healthy volunteers, respectively (P < 0.0001). The subscales scores were also significantly different between two groups. Conclusions: The Persian version of SNOT 22 questionnaire is a valid and reliable instrument for accessing sinonasal diseases in Persianspeaking people

Linguistic nature of reality in Richard Rorty

In this article, our aim is to examine the place of “reality” in Richard Rorty’s thought in view of the important and key discussion of language in the philosophy of this thinker. In other words, we know that with the occurrence of the “linguistic turn” in the middle of the twentieth century, the relationship between language and reality has become one of the central debates of philosophy, especially analytical philosophy, and has become of particular importance. Is it language that determines the external reality for us? Is knowing the world outside the mind possible only through the possibilities that language gives us? And to what extent does the structure of language affect our cognitive pattern? These are only a part of the linguistic concerns that have occupied the minds of contemporary philosophers. The main concern and problem of the present article, which has been approached using a descriptive-analytical method, is to examine the relationship between language and reality in Richard Rorty’s thought and to show how he defends the linguistic structure of having reality. Rorty, following an analytical philosophy that, in addition to detailed analyses of traditional philosophical concepts, like the concepts of truth, meaning, necessity, etc. and by changing the discussion from experience to discussion from language in the direction of pragmatizing the basic principles of positivism, believes that it is trans-lingual (outside our descriptions) and trans-temporal (fixed and unchangeable). The common denominator that Plato found in the outside world and transferred to man in the Cartesian-Kantian tradition is sought in analytic philosophy in language, and so analytic philosophers continue to pursue the traditional philosophy project of providing a trans-historical and eternal framework for the accurate representation of the world. Rorty tries to overcome this view of analytical philosophers with a Darwinist and pragmatic view of language and under the influence of philosophers such as Wittgenstein.For Darwinists, language is a tool among other tools that gives its users the ability to better and more efficiently adapt to their environment and meet their needs. For the likes of Wittgenstein and like-minded people, despite their many and sometimes profound differences, language had an important and pivotal place with its eventual and possibility feature. Influenced by thinkers such as Wittgenstein, and in the context of his Darwinist and pragmatic approach to language, Rorty attributes certain characteristics to language that can be said to influence his whole thought. Firstly, he considers language as a tool like other tools and, therefore, considers it to have no fixed nature and identity. Given that it is not possible to leave the language and on the other hand language has a poetic and metaphorical character, the function of language cannot be a representation of reality and reality can never be available to us naked and as independent of language and descriptions. Therefore, from Rorty’s point of view, reality is a linguistic and constructed matter of language that we humans have invented in cooperation with each other and in accordance with our historical-cultural situation and needs. Of course, Rorty’s point in saying that reality is made by language is by no means that we create reality arbitrarily and as we wish; rather, what is happening is that we are responding to an external stimulus, a response of various sentence types that manifests itself as linguistic reactions

Hyoid bone position in different facial skeletal patterns

Hyoid bone plays a significant role in physiological functions of craniofacial region and it?s position adapts to changes of the head. The purpose of this study was to determine the position of the hyoid bone among subjects with class I, class II and class III skeletal patterns and evaluate the gender differences. One hundred and ten lateral cephalograms (59 females and 51 males) from different skeletal patterns (class I, II and III) were selected. The skeletal patterns were determined according to ANB angle. Using MicroDicom software, different linear and angular measurements (6 variables) was carried out to determine the position of hyoid bone. Intraclass correlation coefficient was used to verify reliability. Descriptive statistics of the variables were calculated and analyzed using two-way ANOVA and Bonferroni statistical methods. The mean distance from the hyoid bone (H) to mandibular plane (MP), to palatal plane (PP), as well as to a third cervical vertebra (C3) was more in males than females (p=0.023, p<0.001, p<0.001 respectively). The mean H to PP distance was significantly more in skeletal class I compared to class III (P=0.01). The mean H to C3 distance was significantly more in skeletal class I compared to class II (P=0.008). The mean angle between H-MP and H-PP did not show any statistical difference among three skeletal classes (p=0.102, P=0.213) and among male and female groups (P=0.172, P=0.904). The hyoid bone is positioned more superior and posterior in females than males and its location differs among different skeletal classes. It is placed more posterior in skeletal class II patterns and more inferior and anterior in skeletal class I patterns

Human cardiac organoids: A recent revolution in disease modeling and regenerative medicine

Three-dimensional (3D) myocardial tissues for studying human heart biology, physiology and pharmacology have recently received lots of attention. Organoids as 3D mini-organs are created from multiple cell types (i.e. induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs)) with other supporting co-cultured cells such as endothelial cells or fibroblasts. Cardiac organoid culture technologies are bringing about significant advances in organ research and allows for the establishment of tissue regeneration and disease modeling. The present review provides an overview of the recent advances in human cardiac organoid platforms in disease biology and for cardiovascular regenerative medicine

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

The global burden of cancer attributable to risk factors, 2010-19 : a systematic analysis for the Global Burden of Disease Study 2019

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Peer reviewe